Originally Posted by Andrew
whats the side effects of say seasamin? becuase im thinking i might need a little boost in lose of fat.
I haven't heard of any known side effects myself. Could hurt your stomach some, especially at first. Probably taking it with plenty of water would help.
This from Derek Charlebois...he sells supplements but in any case he's just quoting studies:
| Sesamin is a naturally occurring lignan found in sesame seeds and oil. A lignan is a molecule that combines with a receptor or another entity acting as an "activator." |
Sesamin has been shown to be a potent PPAR-alpha agonist (Ide et al. 2003). The majority of sesamin research has been done on rats, but the results are very promising for use of sesamin to treat type-2 diabetes and obesity.
Fat can be oxidized in the mitochondria and the peroxisomes of cells, the majority of this oxidation occurring in skeletal muscle cells and the liver.
Mitochonidria: The spherical or elongated organelles in the cytoplasm of nearly all eukaryotic cells, containing genetic material and many enzymes important for cell metabolism, including those responsible for the conversion of food to usable energy. Also called chondriosome.
Peroxisomes: These function to rid the cell of toxic substances, such as hydrogen peroxide, or other metabolites and contain enzymes concerned with oxygen utilization such as D-amino acid oxidase and urease oxidase. Peroxisomes were discovered by Christian de Duve in 1965.
PPARalpha activation by sesamin increases fat oxidation in mitochondria and peroxisomes by increasing the expression of enzymes involved in beta-oxidation of fatty acids (Sirato-Yasumoto et al. 2001).
Of vital important, sesamin increases the expression of the mitochondrial enzyme carnitine palmitoyl transferase (CPT) (Sirato-Yasumoto et al. 2001). CPT, the rate-limiting enzyme in beta-oxidation of fatty acids in skeletal muscle and liver cell mitochondria, is found on the outer membrane of mitochondria and carries fatty acids across the membrane into the mitochondria by binding to them.
Increasing the expression of CPT will allow more fatty acids to be transported into the mitochondria where they can be oxidized. In addition to increasing the oxidation of fat, sesamin supplementation has also been shown to decrease lipogenesis by decreasing lipogenic enzymes in the liver.
Sesamin has been shown to decrease the gene expression of sterol regulatory element binding protein-1 (SREBP-1), acetyl-CoA carboxylase, and fatty acid synthase, among other lipogenic enzymes (Ide et al 2001), which means less fat is esterifized in the liver and therefore less fat is stored in adipose tissue.