Since your main concern is losing weight I would try only resting around 30 seconds between sets. With the less time it will keep your heart rate up and will help burn more calories. Keep in mind it will hamper your strength though. I would recommend a rep range of between 8-12. Theres a lot of research on it and these guys will know more than me but thats what i would recommend. For sets, depending on how fit you are now, i would start with 2 per exercise and limit it to no more than 3-4 exercises per body part until you get in the groove of things for a couple weeks. If your too sore to workout thats no good, and your muscles and tendons will be a mess if you go to hard at first.
I can't justify how important it is to start easy. We want results soon so we think we should do so much but in the end you will only hamper your progress or risk getting injured(which will sideline you even longer)