Glutamine?

[TAURUS]

I reposted/copied this from 'Off to see the Wizard'

Ive been hitting the Lglutamine for the past week, and about 3 or 4th day, my guts where 'rotting'! I figured it may have been some 'very' old crea I tried out recently...Now Im thinking different after reading that...."Glutamine is an important metabolic fuel for white blood cells, fibroblasts (cells involved in tissue repair and healing) and ENTEROCYTES (cells lining the gastrointestinal tract)......" I also read from another source that as much as 50-60 % of glutamine stores are in the 'g-tract', and that the 'tract' will react to the initial supping of Lglutamine by 'activating' or enabling its systollic action to operate optimally. Consequently, some gut problem may exist for a few hours, until the cramps diminish.....! Has anyone had this reaction/lower gut pain before? It only lasted for an hour or so after taking some sodium citrate to ease it away. Im sure now that it wsnt the old crea that did this! Which makes me wonder --- 'I wonder if people that have a supposed 'bad crea reaction' are actually having an Lglutamine reaction from the enterocytes of the g-tract optimizing its systollic action because of cellular glute level restoration'....Any stories or opinions to share?.....GD - the mark-ups are ridiculous....I travel 10 mins down the road to another town to get a supp that sell for 15.95 when it sells for 6 bucks more in my own town(the only place to get it)! With the BS taxes we pay it comes out to more ...

Its been 3 days since the glutegut, and Im feeling fine and Im very very 'regular'! ....

[Darkhorse]

I think it's worthless...Here's a writeup->
"Finally, there are a number of facts that can make glutamine supplementation less appealing. To maintain continually elevated levels of glutamine, one would have to supplement at least every two hours [16]. Glutamine administration also inhibits de novo synthesis of the amino acid in humans, which may make long-term supplementation less effective [20]. In healthy individuals, supplemental glutamine may decrease glutathione levels in some tissues by causing negative feedback [10]. Also, glutamine decreases vascular nitric oxide (NO) production [4]. There is also some concern that the metabolic by-products of glutamine may be toxic in large amounts [18]. However, there have been few reports of adverse events in clinical trials, even with large amounts of glutamine [1, 18].

In conclusion, few studies have demonstrated any sort of conclusive benefit from L-glutamine supplementation in athletes, although the existing evidence does support a small benefit. The most promising effect is a reduced incidence of infection after exhausting exercise, and in this case 5-10 g preworkout and/or postworkout may be effective. It may be especially useful during times of overtraining or high stress, such as on a diet, but this is only in theory. There is little evidence for a direct anabolic or performance enhancing effect of glutamine.

[Dr X]

With all the info I have read on glutamine, and I heard both sides I've since then decided that the only time I use it is while bulking since I'm putting my body under additional stress during that time. Is it any better this way? Who knows.

[TAURUS]

Originally Posted by 0311

I think it's worthless...Here's a writeup->
"Finally, there are a number of facts that can make glutamine supplementation less appealing. To maintain continually elevated levels of glutamine, one would have to supplement at least every two hours [16]. Glutamine administration also inhibits de novo synthesis of the amino acid in humans, which may make long-term supplementation less effective [20]. In healthy individuals, supplemental glutamine may decrease glutathione levels in some tissues by causing negative feedback [10]. Also, glutamine decreases vascular nitric oxide (NO) production [4]. There is also some concern that the metabolic by-products of glutamine may be toxic in large amounts [18]. However, there have been few reports of adverse events in clinical trials, even with large amounts of glutamine [1, 18].

In conclusion, few studies have demonstrated any sort of conclusive benefit from L-glutamine supplementation in athletes, although the existing evidence does support a small benefit. The most promising effect is a reduced incidence of infection after exhausting exercise, and in this case 5-10 g preworkout and/or postworkout may be effective. It may be especially useful during times of overtraining or high stress, such as on a diet, but this is only in theory. There is little evidence for a direct anabolic or performance enhancing effect of glutamine.

...studies are 'hued ' to many degrees....for instence was the subject a diabetic, was the subject KETO, was the subject a vegetarian, was the subject 300 lbs at 35 % bodyfat, was the subject 125 lbs at 5% BF, was the subject an alcoholic, was the subject on any elements, was the subject ...blah blah blah......It helps/works for me.....LGlute makes up to 50% of Nats cellular aminos.......