The primary action is two fold: by parent compound binding to regulatory genes in brain and certain tissues, and within cells, by action of metabolites (the inflammation inducing kind, so you do not want to outcompete product production by mass overload with omega fatty acids).

Use for very short periods of time - no more than 4-6 weeks.

Use in very low doses adjusted to your body mass (the label recommended doses sound quite high), further digging in the lit is recommended to see what loading rates have been studied for theraputic beneficial effects.

Use with others supps that provide protection against membrane lipid oxidation and help protect liver. Hence, use coezyme q10 and sam-e, with milk thistle, as alternate protection against lipid peroxidation and cellular oxidation from exercise in brain, lung, liver, kidney, skin, and skeletal muscle cells.

Do NOT use if your family has a history of colon or prostate cancer, or has a general history of cancer (esp soft tissue types, like liver, lung, brain, or pancreatic cancers).

Do not use if you smoke, or are cycling on steroids (or have in the last 4-6 months). I would avoid a fatty diet, as this compound will affect fatty acid metabolism in liver, resulting in cholestasis (bile acid buildup) if used for prolonged periods.

I neither condone nor directly recommend against use of this compound. It has beens shown to be important in body mass compositional regulation, but also key for turnover of cells, tissue repair, vascularization of tissues, aging in brain, and cancer metastasis. Its control of biosynthesis and storage and release within cells is as complex as its manyfold actions in the body and brain.

However, be forewarned that should you have certain gene regulatory fuckups that allow cells to express arachidonates on their cell surfaces, and if you develop or have certain small tumors, these will vascularize and migrate from their tissue origin, as this compound is involved in cell tissue adhesion loss (what makes like cell stick together and stay in one place). This is a powerful cell signalling compound that has many, many actions in cells, most recently described in the brain.

Note also that turnover rates refer to unbound parent compound. This is a fat soluble structure that easily partitions into cell membranes and may exert effects for weeks after dosing ceases.

Sorta like swallowing nails to get a little iron in your diet. Risky business.

Be so advised.