Nitric Oxide / Arginine and Creatine:
Quote:
The more muscle you gain, the greater the demand on creatine-synthesizing pathways to supply extra creatine to the newly added tissue. Arginine is required for the synthesis of creatine. Almost 2.5 grams of arginine are required to match the daily loss of creatine (as creatinine) in a 70-kg (~154-lb) male. By combining arginine with creatine, more arginine is free to promote nitrogen retention (essential for building muscle) and enhance sodium and water excretion (so-called 'muscle hardening' effects).
"[O]rally administered arginine hydrochloride certainly has anabolic effects by increasing insulin secretion. This molecule has been often used for its anti-asthenic effects in convalescent patients. Weight gain often occurs in patients receiving this therapy. This weight gain is often considered to be a side effect but is to be taking into account when arginine is consumed."
- Arginine researcher Dr. Adrien Schaefer
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