I found a lot of the studies that have to do with the affect of leucine on appetite that were done on rats. I had another that was on people but now I can't find it and don't remember the details.

It's a lot of reading but basically it seems that long term high leucine intake may supress both appetite and growth. However this seems to only be true in the case of low protein diets. The addition of the valine and isoleucine reverses this effect. There is all sorts of antagonism among those aminos which is important (but it was all on rats...).

I'd say, to be on the safe side don't use leucine alone but if one takes in boat loads of protein it's probably no big deal. But I'm with hardgain on the ratio...I don't think it'll make a big difference. Most sups are 2:1:1 like he said.

Edit* I just realized you were talking about a whey supplement. LOL, man don't worry about the bcaa ratio in that. It won't matter. None of this matters except in the context of a bcaa supplement at high levels that you take all the time. You may as well analyze the amino acid profile of a steak.

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If you act sanctimonious I will just list out your logical fallacies until you get pissed off and spew blasphemous remarks.