Who says you have to do more than one set? I do 1 set of 5 reps on bench press some days or 1x3 or 1x5 on squats. It really depends on your goals. If you're aiming for alot of strength then the low sets and low reps with heavy poundages will work. If you're going for hypertrophy then a set of 15 reps may be best (HST template).
IMO it all boils down to what kind of a response you are trying to get out of your muscles. If you want a mix of both strength and size then you need a combination of the two extremes. You can't lift heavy for 15 reps and 5 reps isnt enough for size...so you compromise and do 5 sets of 5 reps. Each set allows for heavy weights and the accumulation of sets allows for muscular fatigue.
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"Pain don't hurt" - Dalton
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