I appreciate the reponses guys.

The ache is the hand in general and I believe it comes plain and simple from the lifting (the grip) itself.

I think I never realized it before because just recently I changed my routine to squads and deadlifts, after reading this site. Before I was dealing with lighter weights, so the "hand ache" didn't come into play.

Like Monstaface said, I just have to toughen up.