My 10 cents: You will cause more problems & have more trouble "hardening" your knuckles than it's worth.
If you "harden" your knuckles, do they become any harder? Or are you just killing sensation in your hands? Looks like you'd end up with arthritis. Strengthening your hands seems like a more viable option. Less chance of a broken bone, bruising, etc. Someone correct me if I'm wrong.
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