CYANOCOBALAMIN INJECTION , USP ( VITAMIN B12)

Pharmacology: Vitamin B12 is essential for growth , cell reproduction, hematopiesis , nucleoprotein and myelin synthesis.

Within 48 hours after injection of 100 to 1000mcg of vitamin b12 , 50 to 98% of the injected dose may appear in the urine. The major portion is excreted within the first 8 hours.

Warnings : Patients who have early Leber's disease ( hereditary optic nerve atrophy ) have been found to suffer severe and swift optic atrophy when treated with vitamin B12.

Hypokalemia and sudden death may occure when severe megaloblastic anemia is treated intensively. Lack of therapeutic response may be due to infection, uremia, concomitant treatment with chloramphenicol or misdiagnosis.

Precautions: Before administering B12 , an intradermal test dose is reommended for patients known to be sensitive to cobalamines. Doses of B12 exceeding 10 mcg daily may produce a hematologic respnse in patients who have a folate deficiency.

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