Here's what I base my thinking on Bull. and I'd appreciate yours and anyone elses take on this--
I've done some research and can't really find anything that shows AI's are bad for lipid profiles. I've also found a lot of info that indicates Nolva can be detrimental to muscle building and some say avoid it entirely based on what seemed to me, at least, to be based on sound info. (I'll dig it up if you like)
Here's some of what I've found.--
FROM: Hellenic Breast Surgeons Society (HBSS), 8 Iassiou Street, Athens, Attica 11521, Greece. firstname.lastname@example.org
CONCLUSIONS: Exemestane (aromasin) appears to have a neutral effect on total cholesterol and HDL levels.
Unlike tamoxifen's positive effect on LDL levels, exemestane does not significantly alter LDL levels. Tamoxifen (Nolvadex)on the other hand increases triglyceride levels, while exemestane results in a beneficial reduction in TRG levels.
FROM: Jules Bordet Institute, Brussels, Belgium.
CONCLUSIONS: Overall, exemestane (aromasin) has no detrimental effect on cholesterol levels and the atherogenic indices, which are well-known risk factors for coronary artery disease. In addition, it has a beneficial effect on TRG(triglycerides) levels.
FROM: Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 424, Houston, Texas 77030, USA. email@example.com
CONCLUSIONS: Long-term adjuvant anastrozole (arimidex) treatment resulted in significantly fewer thromboembolic and cerebrovascular events and a similar incidence of ischemic cardiovascular events compared with tamoxifen (nolvadex).
FROM:Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Bulfinch 327, Fruit Street, Boston, MA 02114, USA. firstname.lastname@example.org
CONCLUSIONS: These results suggest that anastrozole (arimidex)therapy is unlikely to have an adverse effect on bone metabolism when taken over extended periods and may prove to be a valuable method of normalizing testosterone production in men.
Of course you can't mix Nolva with Arimidex or Letrozole because Nolva reduces the blood levels of both. So use Aromasin (and some Nolva if you wish)since Nolva doesn't hurt Aromasin blood levels. Keep the dose low at no more than 20-25mgs/day so estrogen doesn't go too low. Aromasin is only about 65% efficient at suppressing estrogen anyway**. At that dose, Aromasin raises testosterone levels by about 60%, and also help out your free to bound testosterone ratio by lowering levels of Sex Hormone Binding Globulin by about 20%.***
**Zilembo N., Noberasco C., Bajetta E., Martinetti A., Mariani L., Orefici S. Endocrinological and clinical evaluation of exemestane, a new steroidal aromatase inhibitor. Br. J. Cancer, 72: 1007-1012, 1995
***The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 12 5951-5956 Copyright © 2003 by The Endocrine Society