A little bit of info on why aspirin is included in the ECA stack:
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Aspirin is included in the ECA stack to help prolong the effects of ephedrine. Basically as a normalizing procedure the body reacts to ephedrine by producing prostaglandins and adenosine outside the cell, and phosphodiesterase inside the cell. Inside the cell, it has been found that methylxanthines, like caffeine, inhibit the activities of phosphodiesterase. Stimulation of the beta receptors by ephedrine (via noradrenaline) causes an increase of cAMP (cyclic adenosine monophosphate) within the cell. This crucial part of the process that leads to thermogenesis is vulnerable because cAMP is degraded by phosphodiesterase. Outside the cell, aspirin inhibits the peripheral synthesis of prostaglandins. Prostaglandins inhibit the release of noradrenaline in the synaptic junction (before receptor stimulation). So in other words without aspirin (and caffeine), the beta agonistic qualities of ephedrine (via noradrenaline) are practically negated by prostaglandins. Thermogenesis is prolonged because aspirin interferes with this negative feedback mechanism!
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However, there is the current debate that aspirin and other OTC painkillers inhibit protein synthesis and therefore negatively affect your gains.
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