Originally Posted by Sleazy
As mentioned, I think the key is really to start low and work up. When I use too start to high the headaches and side effects would be much more pronounced.
This is definitely where the side effects are more prevalent and it backs up what I have seen it the literature. As Lafit mentioned headaches are a side of yohimbe too. So you've got a double edged sword there and both of these have the potential to increase the side effects of the other. If I were to make an educated guess as to the most dangerous effect I would say hypertensive crises (cause of headache is hypertensive side effect) and arythmia. They are synergistic, at least in cell cultures, in terms of fat loss, i.e. beta 2 antagonist clen + alpha antagonist yohimbe but additive effect on CNS could be potentially very potent and that is not even considering whether yohimbe is a (weak) MAOI. Either way, concurrent use would normally be warned against.
The half life of yohimbe I think is very very short compared to clen (1-2 hours?) so your idea of separating the doses into smaller units, come to think of it, may make a difference. But you more likely need to lower the dose altogether like the others have suggested and start from there. I doubt very much this stuff acutally "spot reduces" like the manufacturers claim.