That's possible. The larger meals may increase your fat storage. In that case I would try and manage the carbs and fat throughout the waking day (eating every 2.5 hrs as you said)...on a fat loss setup they should be lower and easier to get in. You've got carbs and fat regulated in smaller meals and you should be able to hit your macro for protein even if you have to add in an extra shake or something.
I think I'm on the right track but don't take my word for it...I'm always bulking
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