As with the Beta-alanine thread, i'd like to spark some discussion on
Glutamine. There are far too many studies on pubmed for me to sift through all of them, so I'm not going to bother. The following are my thoughts on
Glutamine, please share yours, and hopefully we can gain a general concensus about this suppliments usefulness.
My personal opinion:
(1)Being that
Glutamine is the most abundant amino acid in skeletal muscle, it would make little sense to suppliment with it. Unless you have a serious defciancy, in which case you should see a doctor.
(2)Oral supplimentation with
Glutamine is for the most part pointless. In order to see the effects from it orally,
glutamine will need to pass through the gut, the small intestine, the portal vein, and through the liver. It is degraded at each step of this process, so the oral bioavailability is very low. "SuperDosing" (30+ grams per dose) orally would be the only way see any benifit from it, making it a very expensive suppliment.
(3)In order to maintain hightened levels of
glutamine in the blood, you would need to dose roughly every 2hrs, presumably due to a very short half life. This would be a huge pain in the ass, not to mention a killer to the walet.
(4)Many products containing
glutamine are touted as GH releasing. This includes the various peptides of
glutamine that some retailers charge an arm and a leg for. Dont believe the hype, if your old enough to benifit from GH of any kind, go see a doctor and get script, there is no need to fool with this stuff.
(5)There are just too many variables. I've seen studies that say
Glutamine had a positive effect on protien synthesis in aids patients, on the third sunday of every other month while they stand on thier heads, with an IV full of this stuff. DONT BELIEVE THE HYPE!!! Unless your an aids patient these studies mean nothing to you, and so goes it for any other half assed jackass trying to pass off a study done for one purpose to support something totally different. This happens all the time, dont fall for it.
(6)
Glutamine has been shown to help with GI track complications, and immune function at lower dosages.
(7) Layne Norton
(web page here) as well as many other outstanding and reputable industry professionals have agreed that oral
glutamine supplimentation is all but useless (with the exception of point 6).
Conclusion:
IMO, there is no reason anyone should invest thier hard earned cash in
Glutamine, L-glutamine, or any of the bullshit peptides. Save your money for something that will actually show you some returns. Unless of course your bothered by upset stomachs, or are constantly sick due a shitty immune system.
*Refrence*
http://www.1fast400.com/?ingredients_id=42
I had to have atleast one ...
The Glutamine Info Thread
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