Quote:
Another issue is that, even without the polymerization issue, there is the fact of the solubility factor of weak acids. R-lipoic is a weak acid [pKa=4.7]) and does not have good solubility. Try putting some RLA powder..open a cap if you have one) in a glass of water or vinegar (or anything, for that matter) and see what happens. This is happening in your stomach. It is a well established principle in pharmacology that salts of weak acids generally have much higher aqueous solubility than the free acid.
Therefore, if the material can be taken as a salt (K-RALA® is the potassium salt of R-lipoic acid), the solubility can be increased and there is improved dissolution
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That about summed up the potassium question for me. I like my science simple
Good find, I guess next time around I will purchase some K-RALA over regular R-ALA now that I know the science behind it.
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