It's tricky, but if you incorporate some cardio into your routine, probably on off days, then you can lose fat. However, keep in mind that you'll be lifting heavy (and you'd better be eating too) so you'll also gain muscle. The net weight effect may not be great because of that, although unless you're a fighter or a wrestler like me, you may not care about what you weigh so much as what that weight is composed of. But you should gain muscle mass with the 5x5, even as you burn fat.
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Hybrid Mode